April 28, 2025
2 min learn
Key takeaways:
- After 2 weeks, clascoterone-treated pores and skin had increased hydration ranges in contrast with nontreated pores and skin.
- The researchers additionally noticed no distinction in transepidermal water loss.
Clascoterone cream 1% used twice each day for two weeks had no impact on transepidermal water lack of the pores and skin barrier and elevated facial moisturization, in response to a examine.
“Many pimples drugs are drying and trigger irritation early on within the therapy course of in addition to ongoing irritation with time,” Zoe Diana Draelos, MD, president of Dermatology Consulting Providers, PLLC, advised Healio. “On this specific examine, we have been trying to present that there was no irritation with clascoterone and that the automobile for clascoterone didn’t trigger any difficulties.”
Permitted in 2020, clascoterone cream 1% is a topical androgen receptor indicated for the therapy of pimples vulgaris in sufferers aged 12 years and older. The authors evaluated the cream in a single-center, split-face examine by randomly assigning 50 sufferers (imply age, 31.1 years) to obtain roughly 0.5 g of clascoterone cream 1% to the proper or left facet of the face for two weeks.
After 2 weeks, corneometry readings confirmed that the clascoterone-treated facet of the face had increased hydration ranges in contrast with the nontreated facet of the face (131.3 + 42.9 vs. 113.9 + 36.6; P < .001). In response to Draelos, which means that clascoterone cream 1% could have a gentle moisturization profit on the pores and skin.
Moreover, the researchers noticed no distinction in transepidermal water loss between the handled and untreated pores and skin, indicating no barrier injury.
“Clascoterone cream doesn’t injury the pores and skin barrier, and it could even have some slight barrier enchancment results because of the automobile,” Draelos stated. “Additionally it is suitable with different drugs, similar to benzoyl peroxide or a retinoid.”
The investigators additionally discovered that clascoterone cream 1% didn’t trigger dryness, erythema or irritation at any time level, signaling a positive tolerability profile, which, in response to Draelos, is “a bit bit distinctive within the pimples market.”
“This provides us confidence that sufferers received’t expertise problem utilizing the product both quick time period or long run,” Draelos stated. “If in case you have a affected person that has very delicate pores and skin, or a affected person that has to make use of a number of topical remedies, clascoterone cream 1% can be utilized safely with out problem.”
For extra info:
Zoe Diana Draelos, MD, may be reached at dcs@northstate.internet.
