A research on donor lungs preserved exterior the physique earlier than transplantation demonstrated that the hypothermic oxygenated machine perfusion (HOPE) method is a secure and efficient lung preservation technique, even with whole out-of-body instances approaching 20 hours.
Jitte Jennekens, MSc, organ perfusionist/transplant coordinator on the UMC Utrecht within the Netherlands, introduced the research outcomes at as we speak’s Annual Assembly and Scientific Classes of the Worldwide Society of Coronary heart and Lung Transplantation (ISHLT) in Boston.
“This system is getting used to protect donor livers and kidneys and is being studied in scientific trials for hearts, nevertheless it hasn’t gotten that a lot consideration for lung preservation but,” stated Jennekens.
Ex vivo lung perfusion (EVLP) is a method that enables for donor lungs to be maintained, assessed, and doubtlessly reconditioned exterior of the physique earlier than transplantation. The lungs are related to a pump and a ventilator and perfused with an answer that features as a physiological fluid.
The UMC Utrecht developed its HOPE protocol to soundly prolong perfusion instances, to take care of the viability of the lungs in a single day till the transplantation could be carried out throughout the day.
Donor lungs chosen for EVLP are sometimes transported on ice after which warmed to 37 levels Celsius utilizing a normothermic EVLP (known as nEVLP) protocol for purposeful evaluation. Following nEVLP, the lungs are then returned to ice till the transplant begins.
The HOPE protocol eliminates the second interval on ice by assessing the lungs throughout one hour of nEVLP after which preserving the lungs at 12 levels C till the process.
Jennekens introduced information evaluating the outcomes of 12 circumstances performed utilizing the nEVLP-HOPE protocol with a historic cohort of donor lungs transplanted immediately into sufferers with out ex vivo lung perfusion.
The management cohort included 118 circumstances of lungs transplanted immediately with out perfusion between 2017 and 2022. The circumstances had been carried out between 2022 and 2024 utilizing the HOPE protocol for logistical causes.
No lungs within the nEVLP-HOPE group had been rejected for transplantation, and short-term outcomes had been comparable between the research and management teams.
“Our findings point out that HOPE is a secure and efficient lung preservation technique after a interval of normothermic EVLP,” Jennekens stated.
Jennekens stated the subsequent step is to find out the preservation technique that can be most useful to a selected sort of donor lung.
“Extending perfusion instances for donor lungs exterior of the physique will enable for a future by which donor lungs could be optimized with completely different therapies,” she stated.
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Donor lungs safely preserved as much as 20 hours out-of-body previous to transplantation (2025, April 27)
retrieved 27 April 2025
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